Sun Emily, Shi Yanhong
Department of Neurosciences, Cancer Center, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Department of Neurosciences, Cancer Center, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Exp Neurol. 2015 Jun;268:46-53. doi: 10.1016/j.expneurol.2014.08.005. Epub 2014 Aug 13.
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important roles in the development and functions of the brain. Extensive studies have revealed critical roles for miRNAs in brain development and function. Dysregulation or altered expression of miRNAs is associated with abnormal brain development and pathogenesis of neurodevelopmental diseases. This review serves to highlight the versatile roles of these small RNA molecules in normal brain development and their association with neurodevelopmental disorders, in particular, two closely related neuropsychiatric disorders of neurodevelopmental origin, schizophrenia and bipolar disorder.
微小RNA（miRNA）是单链非编码RNA分子，在大脑发育和功能中发挥重要作用。广泛的研究揭示了miRNA在大脑发育和功能中的关键作用。miRNA的失调或表达改变与大脑发育异常和神经发育疾病的发病机制有关。本综述旨在强调这些小RNA分子在正常大脑发育中的多种作用及其与神经发育障碍的关联，特别是两种密切相关的神经发育起源的神经精神疾病——精神分裂症和双相情感障碍。
