Gürcan Onder
Computer Engineering Department, Ege University, Universite Cad., 35100, Bornova, Izmir, Turkey,
Biol Cybern. 2014 Dec;108(6):713-33. doi: 10.1007/s00422-014-0619-1. Epub 2014 Aug 16.
Correct knowledge of the effective connectivity at the synaptic level in humans is a key prerequisite for increasing our understanding of the operation of the human central nervous system. Unfortunately, none of the current ambitious collaborative neuroscience projects pay enough attention to this topic and are thus unable to completely relate the microlevel properties of the system to its emergent macrolevel behaviors. In this review article, the problem of effective connectivity at the synaptic level in humans is explained, existing and possible computational approaches to fill explanatory gaps are reviewed, and the requisite characteristics of these approaches are considered.
正确了解人类突触水平的有效连接性是增进我们对人类中枢神经系统运作理解的关键前提。不幸的是，当前任何一个雄心勃勃的合作神经科学项目都没有对这个主题给予足够的关注，因此无法将系统的微观层面特性与其涌现的宏观层面行为完全联系起来。在这篇综述文章中，解释了人类突触水平的有效连接性问题，回顾了填补解释空白的现有和可能的计算方法，并考虑了这些方法的必要特征。
