Ganos Christos, Kahl Ursula, Brandt Valerie, Schunke Odette, Bäumer Tobias, Thomalla Götz, Roessner Veit, Haggard Patrick, Münchau Alexander, Kühn Simone
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Neuropsychologia. 2014 Dec;65:297-301. doi: 10.1016/j.neuropsychologia.2014.08.007. Epub 2014 Aug 14.
Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capacity were evaluated outside the scanner. Second, patients were examined with resting state functional magnetic resonance imaging (RS-fMRI) in two states, free ticcing and voluntary tic inhibition. Local synchronization of spontaneous fMRI-signal was analysed with regional homogeneity (ReHo) and differences between both states (free ticcing<tic inhibition) were contrasted. Clinical correlations of the resulting differential ReHo parameters between both states and clinical measures of tic frequency, voluntary tic inhibition and premonitory urges were also performed. ReHo of the left inferior frontal gyrus (IFG) was increased during voluntary tic inhibition compared to free ticcing. ReHo increases were positively correlated with participants׳ ability to inhibit their tics during scanning sessions but also outside the scanner. There was no correlation with ratings of premonitory urges. Voluntary tic inhibition is associated with increased ReHo of the left IFG. Premonitory urges are unrelated to this process.
抽动秽语综合征（GTS）中的抽动类似于正常运动行为的片段，但以一种侵入性、重复性且与情境不符的方式出现。尽管抽动可以根据要求被自主抑制，但这一过程的神经关联仍不清楚。14名无相关合并症的GTS成年患者参与了本研究。首先，在扫描仪外评估抽动严重程度和自主抽动抑制能力。其次，患者在自由抽动和自主抑制抽动两种状态下接受静息态功能磁共振成像（RS-fMRI）检查。用局部一致性（ReHo）分析自发fMRI信号的局部同步性，并对比两种状态（自由抽动＜抽动抑制）之间的差异。还对两种状态下所得的差异ReHo参数与抽动频率、自主抽动抑制和预警冲动的临床测量指标进行了临床相关性分析。与自由抽动相比，在自主抑制抽动期间左侧额下回（IFG）的ReHo增加。ReHo增加与参与者在扫描期间以及扫描仪外抑制抽动的能力呈正相关。与预警冲动评分无相关性。自主抽动抑制与左侧IFG的ReHo增加有关。预警冲动与这一过程无关。
