Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom; Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Germany.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany.
J Psychosom Res. 2014 Jan;76(1):84-7. doi: 10.1016/j.jpsychores.2013.10.014. Epub 2013 Nov 1.
Tics in Gilles de la Tourette syndrome (GTS) are repetitive patterned movements, resembling spontaneous motor behaviour, but escaping voluntary control. Previous studies hypothesised relations between structural alterations in prefrontal cortex of GTS adults and tic severity using voxel-based morphometry (VBM), but could not demonstrate a significant association. The relation between prefrontal cortex structure and tic inhibition has not been investigated.
Here, we used VBM to examine 14 GTS adults without associated comorbidities, and 15 healthy controls. We related structural alterations in GTS to clinical measures of tic severity and tic control.
Grey matter volumes in the right inferior frontal gyrus and the left frontal pole were reduced in patients relative to healthy controls. These changes were not related to tic severity and tic inhibition.
Prefrontal grey matter volume reductions in GTS adults are not related to state measures of tic phenomenology.
Gilles de la Tourette 综合征（GTS）中的抽动是重复的模式运动，类似于自发性运动行为，但不受自愿控制。先前的研究使用基于体素的形态测量学（VBM）假设 GTS 成年人前额叶皮层的结构改变与抽动严重程度之间存在关系，但未能证明存在显著关联。前额叶皮层结构与抽动抑制之间的关系尚未得到研究。
在这里，我们使用 VBM 检查了 14 名没有相关合并症的 GTS 成年人和 15 名健康对照者。我们将 GTS 的结构改变与抽动严重程度和抽动抑制的临床测量值相关联。
与健康对照组相比，患者的右侧额下回和左侧额极的灰质体积减少。这些变化与抽动严重程度和抽动抑制无关。
GTS 成年人前额叶灰质体积减少与抽动现象的状态测量无关。
