Schwartz K E, Saito T
Institute of Clinical Medicine, Syntex Research, Palo Alto, CA 94304.
Atherosclerosis. 1989 Oct;79(2-3):231-6. doi: 10.1016/0021-9150(89)90128-7.
Oral administration of Gardrin (enprostil), a synthetic prostaglandin E2 structural analogue, is associated with a rapid reduction in serum lipoproteins as well as a reduction in meal-stimulated increments for glucose, insulin, and glucose-dependent insulinotropic peptide (GIP). The latter effects appear to be related to be a reduction in carbohydrate absorption. To test the effects of enprostil on an oral fat challenge, 6 healthy males received in random order 35 micrograms enprostil (enp) and placebo (pla), each as a single dose. Thirty minutes following study drug, subjects consumed an 856 kcal test meal with 76 g total fat (80%), 29 g carbohydrate (14%), and 14 g protein (6%). Compared with placebo, enprostil resulted in significant or near significant reductions in insulin, total triglycerides (TG), chylomicron TGs, and GIP while glucose was modestly elevated. The integrated areas under the insulin, GIP, TG, and chylomicron curves were reduced by 59% for insulin and greater than 90% for the remainder, respectively. Thus a single dose of enprostil appears to decrease alimentary lipemia through an effect on chylomicron formation and/or clearance. Other effects, such as a delay in gastric emptying, may be contributory. These observations may have potential therapeutic applications, and additional studies are ongoing to define mechanisms.
口服加德林（恩前列素），一种合成的前列腺素E2结构类似物，与血清脂蛋白的快速降低以及进食刺激后葡萄糖、胰岛素和葡萄糖依赖性促胰岛素多肽（GIP）的增量减少有关。后一种作用似乎与碳水化合物吸收减少有关。为了测试恩前列素对口服脂肪激发试验的影响，6名健康男性按随机顺序分别单次服用35微克恩前列素（enp）和安慰剂（pla）。服用研究药物30分钟后，受试者食用了一顿856千卡的试验餐，其中含有76克总脂肪（80%）、29克碳水化合物（14%）和14克蛋白质（6%）。与安慰剂相比，恩前列素导致胰岛素、总甘油三酯（TG）、乳糜微粒TG和GIP显著或接近显著降低，而葡萄糖略有升高。胰岛素、GIP、TG和乳糜微粒曲线下的积分面积分别降低了59%（胰岛素）和超过90%（其余指标）。因此，单剂量恩前列素似乎通过对乳糜微粒形成和/或清除的影响来降低食后血脂。其他作用，如胃排空延迟，可能也有作用。这些观察结果可能具有潜在的治疗应用价值，目前正在进行更多研究以确定其机制。
