Madarame Hiroo, Ogihara Kikumi, Kimura Moe, Nagai Makoto, Omatsu Tsutomu, Ochiai Hideharu, Mizutani Tetsyuya
Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
Laboratory of Pathology, Department of Environmental Hygine, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
Vet Microbiol. 2014 Sep 17;173(1-2):136-40. doi: 10.1016/j.vetmic.2014.07.012. Epub 2014 Jul 29.
A pneumonia virus of mice (PVM) from an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS) was detected and genetically characterized. The affected hedgehog had a nonsuppurative encephalitis with vacuolization of the white matter, and the brain samples yielded RNA reads highly homogeneous to PVM strain 15 (96.5% of full genomic sequence homology by analysis of next generation sequencing). PVM antigen was also detected in the brain and the lungs immunohistochemically. A PVM was strongly suggested as a causative agent of encephalitis of a hedgehog with suspected WHS. This is a first report of PVM infection in hedgehogs.
检测到一只疑似患有刺猬颤抖综合征（WHS）的非洲刺猬（Atelerix arbiventris）携带小鼠肺炎病毒（PVM），并对其进行了基因特征分析。受感染的刺猬患有非化脓性脑炎，白质出现空泡化，脑样本产生的RNA读数与PVM 15株高度同源（通过下一代测序分析，全基因组序列同源性为96.5%）。免疫组织化学方法也在脑和肺中检测到了PVM抗原。强烈提示PVM是一只疑似患有WHS的刺猬脑炎的病原体。这是刺猬感染PVM的首次报告。
