从日本大鼠群体中分离出的新型小鼠肺炎病毒（PVM）及其特性。

New isolates of pneumonia virus of mice (PVM) from Japanese rat colonies and their characterization.

作者信息

Miyata H, Kishikawa M, Kondo H, Kai C, Watanabe Y, Ohsawa K, Sato H

机构信息

Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, Japan.

出版信息

Exp Anim. 1995 Apr;44(2):95-104. doi: 10.1538/expanim.44.95.

DOI:10.1538/expanim.44.95

PMID:7601231

Abstract

Two virus strains were isolated from the lungs of athymic rats and mice used as sentinel animals in 2 colonies of laboratory rats in Japan in which antibodies to the pneumonia virus of mice (PVM) had been detected. The new isolates were identified as PVM by the following characteristics: RNA virus, susceptibility to ether treatment, long filamentous viral structure in the cytoplasm of infected cells, and hemagglutinating activity in various erythrocytes, including those of mice and rats. In addition, cross neutralization with the prototype of PVM (No. 15 strain) was observed. This is the first report of the isolation of PVM from laboratory animals in Japan.

摘要

在日本的2个实验大鼠群落中，作为哨兵动物的无胸腺大鼠和小鼠的肺部分离出两种病毒株，在这些群落中已检测到针对小鼠肺炎病毒（PVM）的抗体。通过以下特征将新分离株鉴定为PVM：RNA病毒、对乙醚处理敏感、感染细胞胞质中有长丝状病毒结构以及对包括小鼠和大鼠红细胞在内的各种红细胞具有血凝活性。此外，观察到与PVM原型（15号株）的交叉中和作用。这是日本首次从实验动物中分离出PVM的报告。