Wong Andy K O, Beattie Karen A, Min Kevin K H, Merali Zamir, Webber Colin E, Gordon Christopher L, Papaioannou Alexandra, Cheung Angela M W, Adachi Jonathan D
Department of Medicine, McMaster University, Hamilton, ON, Canada.
Department of Medicine, McMaster University, Hamilton, ON, Canada.
J Clin Densitom. 2015 Apr-Jun;18(2):260-9. doi: 10.1016/j.jocd.2014.07.004. Epub 2014 Aug 13.
The previous article in this 3-part series demonstrated short-term precision and validity for volumetric bone outcome quantification using in vivo peripheral (p) quantitative computed tomography (pQCT) and magnetic resonance imaging (MRI) modalities at resolutions 200 μm or higher. However, 1-yr precision error and clinically significant references are yet to be reported for these modalities. This study examined 59 women with mean age of 75 ± 9 yr and body mass index of 26.84 ± 4.77 kg/m², demonstrating the lowest 1-yr precision error, standard errors of the estimate, and least significant change values for high-resolution (hr) pQCT followed by pQCT, and 1.0-T pMRI for all volumetric bone outcomes except trabecular number. Like short-term precision, 1-yr statistics for trabecular separation were similar across modalities. Excluding individuals with a previous history of fragility fractures, or who were current users of antiresorptives reduced 1-yr change for bone outcomes derived from pQCT and pMR images, but not hr-pQCT images. In Part II of this 3-part series focused on trimodality comparisons of 1-yr changes, hr-pQCT was recommended to be the prime candidate for quantifying change where smaller effect sizes are expected, but pQCT was identified as a feasible alternative for studies expecting larger changes.
在这个分为三部分的系列文章中，上一篇文章展示了在分辨率为200μm或更高时，使用体内外周（p）定量计算机断层扫描（pQCT）和磁共振成像（MRI）方法进行骨体积结果定量的短期精度和有效性。然而，这些方法的1年精度误差和具有临床意义的参考值尚未见报道。本研究对59名平均年龄为75±9岁、体重指数为26.84±4.77kg/m²的女性进行了检查，结果表明，对于所有骨体积结果（除骨小梁数量外），高分辨率（hr）pQCT的1年精度误差、估计标准误差和最小有意义变化值最低，其次是pQCT和1.0-T pMRI。与短期精度一样，各方法之间骨小梁间距的1年统计数据相似。排除有脆性骨折既往史或正在使用抗吸收药物的个体后，pQCT和pMR图像得出的骨结果的1年变化减小，但hr-pQCT图像得出的骨结果不受影响。在这个分为三部分的系列文章的第二部分中，重点关注了1年变化的三模态比较，对于预期效应量较小的情况，建议使用hr-pQCT作为量化变化的主要候选方法，但对于预期变化较大的研究，pQCT被确定为一种可行的替代方法。
