Department of Medical and Surgical Sciences, University of Padova, Italy.
J Clin Densitom. 2011 Jul-Sep;14(3):367-73. doi: 10.1016/j.jocd.2011.05.002. Epub 2011 Jul 1.
The aim of this study was to determine the reproducibility for in vivo measurements at the radius and tibia for trabecular and cortical parameters, bone geometry, and bone strength indices with the peripheral quantitative computed tomography (pQCT) XCT 3000. We performed 3 repeated scans within 2mo at the radius (N=18) and tibia (N=16) on healthy, premenopausal women, aged 22-35 yrs and report precision measures including %coefficient of variation (%CV) and least significant changes (LSCs). For the radius, we studied 2 sections (4% and 33% of total length) and for the tibia, 3 sections (4%, 38%, and 66% of total length). Reproducibility for radius at 33% and tibia at every site was good (%CV ranged from 0.02% to 2.19%). The precision error for the distal 4% radius was, however, higher. The reproducibility at the distal radius improved when we considered only the scans with a change of ± 10mm(2) in the radius total area at this site (%CV from 0.87% to 2.25%). This study showed that, when follow-up measurements are carefully obtained, pQCT yields excellent reproducibility at both the radius and tibia. These precision errors, in conjunction with changes in LSC for the pQCT measures, are useful for research and potential clinical applications.
本研究旨在确定在活体状态下，使用外周定量计算机断层扫描（pQCT） XCT 3000 对桡骨和胫骨的小梁和皮质参数、骨几何形状和骨强度指数进行重复测量的可重复性。我们对 18 名健康、绝经前、年龄在 22-35 岁的女性的桡骨（18 名）和胫骨（16 名）进行了 3 次重复扫描，在 2 个月内完成，并报告了精度测量值，包括%变异系数（%CV）和最小有意义变化（LSCs）。对于桡骨，我们研究了 2 个节段（总长度的 4%和 33%），对于胫骨，研究了 3 个节段（总长度的 4%、38%和 66%）。桡骨 33%处和胫骨各部位的重复性较好（%CV 范围为 0.02%-2.19%）。然而，远端 4%桡骨的精度误差较高。当我们仅考虑在该部位桡骨总区域变化±10mm²的扫描时，远端桡骨的可重复性提高（%CV 从 0.87%降至 2.25%）。本研究表明，当仔细获得随访测量值时，pQCT 在桡骨和胫骨均能获得优异的可重复性。这些精度误差与 pQCT 测量值的 LSC 变化一起，对于研究和潜在的临床应用非常有用。
