Macklon Kirsten Tryde, Ernst Erik, Andersen Anders Nyboe, Andersen Claus Yding
The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
The Fertility Clinic, Aarhus University Hospital, Skejby, Denmark.
Reprod Biomed Online. 2014 Oct;29(4):452-6. doi: 10.1016/j.rbmo.2014.06.016. Epub 2014 Jul 15.
Cryopreservation of ovarian tissue is one way of preserving fertility in young women with a malignant disease or other disorders that require gonadotoxic treatment. The purpose of the study was to explore how many women remained interested in continued cryostorage of their ovarian tissue beyond an initial 5-year period. Between 1999 and 2006, a total of 201 girls and young women had one ovary cryopreserved for fertility preservation in Denmark. One hundred of these met our inclusion criteria, which included a follow-up period of at least 5 years, and were mailed a questionnaire. The response rate was 95%. Sixteen of the patients (17%) stated that they wanted disposal of their tissue; the main reason was completion of family (63%). The mean age of those requesting disposal was 36.6 years, whereas those still wanting their tissue stored were significantly younger, with a mean age of 33.0 years (P < 0.008). In conclusion, most women with ovarian tissue cryobanked requested continued cryostorage after an initial period of at least 5 years. The main reason for requesting disposal was successful completion of a family.
卵巢组织冷冻保存是为患有恶性疾病或其他需要性腺毒性治疗的年轻女性保留生育能力的一种方法。本研究的目的是探讨有多少女性在最初的5年期限之后仍对继续冷冻保存其卵巢组织感兴趣。1999年至2006年期间，丹麦共有201名女孩和年轻女性为保留生育能力而冷冻了一侧卵巢。其中100名符合我们的纳入标准，包括至少5年的随访期，并收到了一份调查问卷。回复率为95%。16名患者（17%）表示希望处理掉她们的组织；主要原因是已组建家庭（63%）。请求处理组织的患者的平均年龄为36.6岁，而仍希望保存其组织的患者明显更年轻，平均年龄为33.0岁（P<0.008）。总之，大多数冷冻保存了卵巢组织的女性在至少5年的初始期限后仍要求继续冷冻保存。请求处理组织的主要原因是已成功组建家庭。
