Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovak Republic.
Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovak Republic.
Carbohydr Polym. 2014 Nov 4;112:603-7. doi: 10.1016/j.carbpol.2014.06.050. Epub 2014 Jun 24.
Carboxymethyl derivatives (CM-derivatives) of α,β-mannans from yeasts, Saccharomyces cerevisiae β-glucan and dextran (α-glucan) were found to possess strong antioxidant activities against reactive hydroxyl radicals (OH*) compared to underivatized polysaccharides. When CM-derivatives having similar DS (0.41-0.45) were compared, the antioxidant activity decreased in order CM-mannan>CM-β-glucan>CM-dextran. Moreover, the antioxidant activities against OH* increased with increasing degree of substitution (DS) of polysaccharides. The CM-mannan and CM-dextran with the highest DS (0.73 and 1.1, respectively) were the strongest antioxidants and their degradation by OH* decreased with increased carboxymethylation. The scavenging abilities of CM-polysaccharides against stable DPPH radical (DPPH) were lower than those of original underivatized ones. Also this scavenging property against DPPH was lower compared to antioxidant effect against OH*.
酵母α，β-甘露聚糖、酿酒酵母β-葡聚糖和葡聚糖（α-葡聚糖）的羧甲基衍生物（CM-衍生物）被发现具有比未衍生多糖更强的抗活性羟基自由基（OH*）的抗氧化活性。当比较具有相似取代度（DS）（0.41-0.45）的 CM-衍生物时，抗氧化活性按 CM-甘露聚糖>CM-β-葡聚糖>CM-葡聚糖的顺序降低。此外，多糖的取代度（DS）越高，对 OH的抗氧化活性越高。取代度最高的 CM-甘露聚糖和 CM-葡聚糖（分别为 0.73 和 1.1）是最强的抗氧化剂，它们对 OH的降解随羧甲基化的增加而减少。CM-多糖对稳定的 DPPH 自由基（DPPH）的清除能力低于未衍生的原始多糖。此外，与 OH*的抗氧化作用相比，其对 DPPH 的清除能力较低。
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