Huang Jianfeng, Zhang Mingzhi, Zhang Xiaobo, Lu Aizhen, Wang Libo, Chen Chao
Pulmonology Department, Children's Hospital of Fudan University, Shanghai, China.
Acta Paediatr. 2014 Dec;103(12):e544-7. doi: 10.1111/apa.12767. Epub 2014 Sep 11.
IFN-γ, an essential cytokine in the viral cell-mediated immune response, has been associated with the pathogenesis of respiratory syncytial virus (RSV) bronchiolitis and to the severity of the infection. The aim of this study was to investigate whether IFN-γ CA microsatellite (rs3138557) polymorphism was associated with susceptibility to RSV in Chinese Han children and with the severity of the infection.
The IFN-γ CA microsatellite was tested in 218 RSV bronchiolitis inpatients and 303 healthy controls, and the severity of the RSV bronchiolitis was evaluated using a standardised respiratory scoring system.
The frequencies of CA12+/CA12+, CA12+/CA12- and CA12-/CA12- in the 218 RSV bronchiolitis patients and 303 controls were approximately 11% versus 19%, 55% versus 53% and 34% versus 28%, respectively. The gene polymorphism of IFN-γ CA repeats between the two groups was statistically different. The clinical respiratory scores of RSV bronchiolitis cases with CA12+/CA12+ and CA12+/CA12- were 2.84 ± 0.40 (SD) and 2.95 ± 0.44 (SD), respectively, and these were significantly lower than the 3.1 ± 0.36 (SD) score for those with CA12-/CA12-.
IFN-γ CA microsatellite polymorphism was associated with the susceptibility of Chinese Han children to RSV and the severity of the infection.
干扰素-γ是病毒细胞介导免疫反应中的一种重要细胞因子，与呼吸道合胞病毒（RSV）细支气管炎的发病机制及感染严重程度有关。本研究旨在探讨干扰素-γ CA微卫星（rs3138557）多态性与中国汉族儿童RSV易感性及感染严重程度是否相关。
对218例RSV细支气管炎住院患儿和303例健康对照进行干扰素-γ CA微卫星检测，并采用标准化呼吸评分系统评估RSV细支气管炎的严重程度。
218例RSV细支气管炎患者和303例对照中，CA12+/CA12+、CA12+/CA12-和CA12-/CA12-的频率分别约为11%对19%、55%对53%和34%对28%。两组间干扰素-γ CA重复序列的基因多态性有统计学差异。CA12+/CA12+和CA12+/CA12-的RSV细支气管炎病例的临床呼吸评分分别为2.84±0.40（标准差）和2.95±0.44（标准差），显著低于CA12-/CA12-病例的3.1±0.36（标准差）评分。
干扰素-γ CA微卫星多态性与中国汉族儿童RSV易感性及感染严重程度相关。
