6-羟基多巴胺（6-OHDA）对大鼠脑内自由基清除剂的区域效应。

Regional effects of 6-hydroxydopamine (6-OHDA) on free radical scavengers in rat brain.

作者信息

Perumal A S, Tordzro W K, Katz M, Jackson-Lewis V, Cooper T B, Fahn S, Cadet J L

机构信息

Neurological Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032.

出版信息

Brain Res. 1989 Dec 11;504(1):139-41. doi: 10.1016/0006-8993(89)91611-9.

DOI:10.1016/0006-8993(89)91611-9

PMID:2513085

Abstract

Superoxide dismutase (SOD), catalase, glutathione (GSH), and glutathione peroxidase (GSH-Px) were measured in the caudate-putamen (CPu), the hippocampus (HIP), and the brainstem (BS) of the brains of control animals and of rats treated with one intracerebroventricular infusion of 6-hydroxydopamine (6-OHDA). Injection of 6-OHDA resulted in significant decreases in the activity of SOD in the CPu, the BS, and in the HIP. There were decreases in catalase in the CPu and in the BS, but not in the HIP. GSH was reduced in the CPu and the BS but not changed in the HIP. There were small decreases in the activity of GSH-Px only in the BS. These changes may be secondary to the production of free radicals after the infusion of 6-OHDA in rat brain.

摘要

在对照动物以及经脑室内注射一次6-羟基多巴胺（6-OHDA）处理的大鼠的大脑中，检测了尾状核-壳核（CPu）、海马体（HIP）和脑干（BS）中的超氧化物歧化酶（SOD）、过氧化氢酶、谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GSH-Px）。注射6-OHDA导致CPu、BS和HIP中的SOD活性显著降低。CPu和BS中的过氧化氢酶减少，但HIP中未减少。CPu和BS中的GSH减少，但HIP中未改变。仅BS中的GSH-Px活性有小幅下降。这些变化可能继发于大鼠脑内注射6-OHDA后自由基的产生。