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Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.小鼠狐猴灵长类动物血浆淀粉样蛋白的年龄相关演变：与细胞内淀粉样蛋白沉积的关系。
Neurobiol Aging. 2015 Jan;36(1):149-56. doi: 10.1016/j.neurobiolaging.2014.07.017. Epub 2014 Jul 18.
2
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.在食蟹猕猴灵长类动物中，α-突触核蛋白的年龄依赖性聚集。
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3
Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus.小鼠狐猴（Microcebus murinus）大脑皮质中tau蛋白免疫反应性积聚和β淀粉样蛋白沉积的定量分析。
Acta Neuropathol. 1997 Aug;94(2):131-9. doi: 10.1007/s004010050684.
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Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus).针对老年非人类灵长类动物（Microcebus murinus）的淀粉样蛋白-β的免疫接种。
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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.阿尔茨海默病Tg2576转基因小鼠模型中脑、脑脊液和血浆淀粉样β蛋白的年龄依赖性变化。
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Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.人类、非人类灵长类动物、犬类以及阿尔茨海默病样转基因小鼠模型大脑中的焦谷氨酸盐-3 淀粉样蛋白沉积。
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Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease.衰老和淀粉样β蛋白沉积对阿尔茨海默病Tg2576小鼠模型中纤溶酶原激活剂和纤溶酶原激活剂抑制剂-1的影响。
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Front Aging Neurosci. 2018 Feb 14;10:35. doi: 10.3389/fnagi.2018.00035. eCollection 2018.
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The use of nonhuman primate models to understand processes in Parkinson's disease.利用非人类灵长类动物模型来理解帕金森病中的相关过程。
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7
Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer's disease mouse model.内嗅皮层功能障碍可以通过抑制阿尔茨海默病小鼠模型中的小胶质细胞 RAGE 来挽救。
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Synaptic activity and Alzheimer's disease: a critical update.突触活动与阿尔茨海默病：重要更新
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本文引用的文献

1
Additional use of Aβ₄₂/Aβ₄₀ ratio with cerebrospinal fluid biomarkers P-tau and Aβ₄₂ increases the level of evidence of Alzheimer's disease pathophysiological process in routine practice.在常规实践中，将β淀粉样蛋白42（Aβ₄₂）/β淀粉样蛋白40（Aβ₄₀）比值与脑脊液生物标志物磷酸化tau蛋白（P-tau）和Aβ₄₂一起使用，可提高阿尔茨海默病病理生理过程的证据水平。
J Alzheimers Dis. 2014;41(2):377-86. doi: 10.3233/JAD-131838.
2
Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.淀粉样β免疫接种使脉络丛中铁沉积和脑微出血恶化。
Neurobiol Aging. 2013 Nov;34(11):2613-22. doi: 10.1016/j.neurobiolaging.2013.05.013. Epub 2013 Jun 22.
3
Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels.脑脊液 Aβ1-40 可改善 P-tau181P 水平中等的患者的痴呆鉴别诊断。
J Alzheimers Dis. 2013;36(4):759-67. doi: 10.3233/JAD-130107.
4
Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models.人脑中 Abeta 免疫反应性物质的积累证据。
Life Sci. 2012 Dec 10;91(23-24):1141-7. doi: 10.1016/j.lfs.2012.05.020. Epub 2012 Jun 13.
5
AβPP accumulation and/or intraneuronal amyloid-β accumulation? The 3xTg-AD mouse model revisited.AβPP 积累和/或细胞内淀粉样-β 积累？重新审视 3xTg-AD 小鼠模型。
J Alzheimers Dis. 2012;28(4):897-904. doi: 10.3233/JAD-2011-111529.
6
Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment.在轻度认知障碍中，血浆 Aβ 与 PET PiB 结合呈负相关。
Neurology. 2011 Jul 12;77(2):125-31. doi: 10.1212/WNL.0b013e318224afb7. Epub 2011 Jun 29.
7
Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.阿尔茨海默病患者血浆淀粉样蛋白-β水平的荟萃分析。
J Alzheimers Dis. 2011;26(2):365-75. doi: 10.3233/JAD-2011-101977.
8
Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.3xTg-AD 小鼠脑内的 APP，而非游离的 Aβ 肽：对 tau 与 Aβ 介导的阿尔茨海默病神经退行性变的影响。
J Neurosci. 2011 May 25;31(21):7691-9. doi: 10.1523/JNEUROSCI.6637-10.2011.
9
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.为了定义阿尔茨海默病的临床前阶段：来自美国国家老龄化研究所-阿尔茨海默病协会工作组关于阿尔茨海默病诊断指南的建议。
Alzheimers Dement. 2011 May;7(3):280-92. doi: 10.1016/j.jalz.2011.03.003. Epub 2011 Apr 21.
10
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy.阿尔茨海默病小鼠模型中的稳健淀粉样蛋白清除为淀粉样蛋白-β免疫疗法的机制提供了新的见解。
J Neurosci. 2011 Mar 16;31(11):4124-36. doi: 10.1523/JNEUROSCI.5077-10.2011.

小鼠狐猴灵长类动物血浆淀粉样蛋白的年龄相关演变：与细胞内淀粉样蛋白沉积的关系。

Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.

作者信息

Roy Maggie, Cardoso Cécile, Dorieux Olène, Malgorn Carole, Epelbaum Stéphane, Petit Fanny, Kraska Audrey, Brouillet Emmanuel, Delatour Benoît, Perret Martine, Aujard Fabienne, Dhenain Marc

机构信息

CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France; Research Center on Aging, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.

出版信息

Neurobiol Aging. 2015 Jan;36(1):149-56. doi: 10.1016/j.neurobiolaging.2014.07.017. Epub 2014 Jul 18.

DOI:10.1016/j.neurobiolaging.2014.07.017
PMID:25131002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4268267/
Abstract

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks, and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic Aβ, and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared with young ones. Histologic evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic Aβ was negatively correlated with the density of neurons accumulating deposits of Aβ.

摘要

阿尔茨海默病（AD）是最常见的与年龄相关的神经退行性疾病。大脑中β淀粉样肽（Aβ）沉积是其特征之一，血浆Aβ的检测被认为是AD动物模型中抗淀粉样蛋白药物疗效的生物标志物。然而，文献中几乎从未涉及动物模型中与年龄相关的血浆Aβ调节。小鼠狐猴灵长类动物被用作正常和类AD脑老化的模型。在此，我们研究了年龄对58只年龄在1至10岁的小鼠狐猴血浆Aβ的影响。一部分动物血浆Aβ水平较高，与年轻动物相比，老年动物中血浆Aβ水平高的动物比例更高。对其中一些动物的大脑进行了组织学评估，以评估细胞外和细胞内淀粉样蛋白负荷。在老年狐猴中，血浆Aβ与积累Aβ沉积物的神经元密度呈负相关。