Cavicchi S, Guerra D, Natali V, Giorgi G, Pezzoli C, Villani L
Department of Evolutionary and Experimental Biology, University of Bologna, Italy.
Dev Genet. 1989;10(5):386-92. doi: 10.1002/dvg.1020100506.
An analysis of the modifiers affecting the expression of the vg gene was performed. We selected for weak and strong expression of the vg mutant in F2 segregating populations obtained by crossing a vestigial stock with an Oregon laboratory stock (O) and with a wild strain (B) captured near Bologna, Italy. The selection for enlarged wings was more effective in the vg B population where wild wings appeared from the 10th generation. The assay of the three major chromosomes showed that the modifiers are located on chromosomes 2 and 3. The mutant imaginal disc cell death phenotype is evident in vg/vg strains that have a wild-type wing phenotype. It is suggested that the selected modifiers do not prevent cell death but induce regenerative growth.
对影响vg基因表达的修饰因子进行了分析。我们在通过将残翅品系与俄勒冈实验室品系（O）以及在意大利博洛尼亚附近捕获的野生菌株（B）杂交获得的F2分离群体中，选择了vg突变体的弱表达和强表达。在vg B群体中，从第10代开始出现野生型翅膀，对翅膀增大的选择更有效。对三条主要染色体的检测表明，修饰因子位于第2和第3号染色体上。在具有野生型翅膀表型的vg/vg品系中，突变的成虫盘细胞死亡表型很明显。有人提出，所选的修饰因子不会阻止细胞死亡，而是诱导再生生长。
