Sklan D, Yosefov T, Friedman A
Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
Int J Vitam Nutr Res. 1989;59(3):245-50.
Chicks were fed diets containing, 0, 0.85 and 350 mg/kg vitamin A and 1 g/kg beta-carotene or canthaxanthin from hatching. Carotene increased and canthaxanthin depressed plasma and hepatic vitamin A concentrations. High vitamin A levels decreased the concentration of both carotenoids. Neither carotene nor canthaxanthin affected intestinal carotene cleavage in vitro. T-lymphocyte proliferative responses were decreased at low vitamin A intakes and enhanced at the high vitamin A intake. Carotene and canthaxanthin fed with 0.85 mg/kg vitamin A had no effect on immune response and with 350 mg/kg vitamin A prevented the enhancement of the proliferative response. It is concluded that immune response in the chick is modulated by vitamin A; carotene and canthaxanthin effects are probably due to influences on vitamin A metabolism.
雏鸡从孵化起就被喂食含有0、0.85和350毫克/千克维生素A以及1克/千克β-胡萝卜素或角黄素的日粮。胡萝卜素会增加而角黄素会降低血浆和肝脏中的维生素A浓度。高维生素A水平会降低两种类胡萝卜素的浓度。胡萝卜素和角黄素在体外均不影响肠道类胡萝卜素的裂解。低维生素A摄入量时T淋巴细胞增殖反应降低，高维生素A摄入量时则增强。与0.85毫克/千克维生素A一起喂食的胡萝卜素和角黄素对免疫反应没有影响，而与350毫克/千克维生素A一起喂食时则可防止增殖反应增强。得出的结论是，雏鸡的免疫反应受维生素A调节；胡萝卜素和角黄素的作用可能是由于对维生素A代谢的影响。
