在有氧条件下通过氧化 C-C 键断裂从醛类中一般合成 ynones。
A general synthesis of ynones from aldehydes via oxidative C-C bond cleavage under aerobic conditions.
机构信息
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School , Shenzhen, 518055, China.
出版信息
J Am Chem Soc. 2014 Sep 3;136(35):12233-6. doi: 10.1021/ja506352b. Epub 2014 Aug 20.
PMID:25133731
Abstract
We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the desired ynone through an in situ C-C bond oxidative cleavage using molecular oxygen.
摘要
我们描述了一种从易得的醛和高价炔基碘化物直接合成各种炔酮的方法。在这种方法中，金催化剂和仲胺协同作用生成三取代烯丙基醛，它可以通过原位 C-C 键氧化裂解使用分子氧转化为所需的炔酮。
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