细胞系70Z/3的一种γ干扰素无反应变体IFN-4，可被佛波醇肉豆蔻酸酯乙酸盐部分挽救。
A gamma interferon-unresponsive variant of cell line 70Z/3, IFN-4, can be partially rescued by phorbol myristate acetate.
作者信息
Emery D W, Rooney J W, Sibley C H
机构信息
Department of Genetics, University of Washington, Seattle 98195.
出版信息
Mol Cell Biol. 1989 Nov;9(11):5231-3. doi: 10.1128/mcb.9.11.5231-5233.1989.
Abstract
Lipopolysaccharide (LPS) and gamma interferon (IFN-gamma) induce kappa transcription in 70Z/3 cells by different mechanisms; LPS treatment induces both NF-kappa B and OTF-2 transcription factors, but IFN-gamma treatment does not. We have dissected these two activation pathways by selecting and analyzing an LPS+ IFN- variant of 70Z/3.
摘要
脂多糖（LPS）和γ干扰素（IFN-γ）通过不同机制诱导70Z/3细胞中的κ转录；LPS处理可诱导NF-κB和OTF-2转录因子，而IFN-γ处理则不能。我们通过选择和分析70Z/3的LPS + IFN-变体来剖析这两种激活途径。
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