褪黑素可改善经诺龙处理的Wistar大鼠在强迫游泳试验诱导的氧化应激中的精子质量。
Melatonin improve the sperm quality in forced swimming test induced oxidative stress in nandrolone treated Wistar rats.
作者信息
Minaii Bagher, Moayeri Ardeshir, Shokri Saeed, Habibi Roudkenar Mehryar, Golmohammadi Taghi, Malek Fatemeh, Barbarestani Mohammad
机构信息
Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.AND Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
Acta Med Iran. 2014;52(7):496-504.
This study investigates the effects of melatonin on the sperm quality and testis weight after the combination of swimming exercise and nandrolone decanoate (DECA). Two groups of male Wistar rats were treated for eight weeks as follows; group A consist of CO (control), Sham, N (DECA), S (swimming) and NS (DECA plus swimming); and group B: Sham M (sham melatonin), M (melatonin), MN (melatonin plus DECA), MS (melatonin plus swimming), MNS (melatonin, DECA plus swimming). The motility of sperm was significantly improved in melatonin groups in comparison to N, S and NS groups (P≤0.05). The left testes weight was decreased in N, NS and MNS groups, and the right testes weight was decreased in N,S,NS, MS and MNS groups in compare with the control group. This study concluded that melatonin probably could improve the sperm motility and sex organs weight after the combination of DECA and exercise.
本研究调查了褪黑素对游泳运动与癸酸诺龙（DECA）联合使用后精子质量和睾丸重量的影响。将两组雄性Wistar大鼠按如下方式处理八周；A组包括CO（对照组）、假手术组、N（DECA组）、S（游泳组）和NS（DECA加游泳组）；B组：假手术M组（假褪黑素组）、M组（褪黑素组）、MN组（褪黑素加DECA组）、MS组（褪黑素加游泳组）、MNS组（褪黑素、DECA加游泳组）。与N组、S组和NS组相比，褪黑素组精子活力显著提高（P≤0.05）。与对照组相比，N组、NS组和MNS组左侧睾丸重量降低，N组、S组、NS组、MS组和MNS组右侧睾丸重量降低。本研究得出结论，褪黑素可能在DECA与运动联合使用后改善精子活力和性器官重量。
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