Division of Hematology/Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. University of Pittsburgh Cancer Institute Melanoma and Skin Cancer Program, Pittsburgh, Pennsylvania.
Clin Cancer Res. 2014 Nov 1;20(21):5346-8. doi: 10.1158/1078-0432.CCR-14-1121. Epub 2014 Aug 18.
Melanoma brain metastases (MBM) present a significant clinical challenge. Molecular profiling of MBM is useful to identify molecular pathways, such as the PI3K pathway, that are specifically and differentially altered in MBM. Therapeutic studies should recruit patients with MBM and prospective tissue collection will lay the foundation for further advances.
黑色素瘤脑转移（MBM）是一个重大的临床挑战。MBM 的分子谱分析有助于识别分子途径，如 PI3K 途径，这些途径在 MBM 中具有特异性和差异性改变。治疗研究应招募 MBM 患者，并进行前瞻性组织采集，为进一步的进展奠定基础。
