哺乳动物大脑中的DNA修饰。
DNA modifications in the mammalian brain.
作者信息
Shin Jaehoon, Ming Guo-Li, Song Hongjun
机构信息
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). doi: 10.1098/rstb.2013.0512.
DNA methylation is a crucial epigenetic mark in mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for mammalian neuronal functions, and learning and memory. In this review, we first summarize recent discoveries and fundamental principles of DNA modifications in the general epigenetics field. We then describe the profiles of different DNA modifications in the mammalian brain genome. Finally, we discuss roles of DNA modifications in mammalian brain development and function.
DNA甲基化是哺乳动物发育、基因组印记、X染色体失活、染色体稳定性以及抑制寄生性DNA元件过程中一种至关重要的表观遗传标记。神经元中的DNA甲基化也被认为在哺乳动物的神经元功能以及学习和记忆方面发挥着重要作用。在这篇综述中，我们首先总结了表观遗传学领域中DNA修饰的最新发现和基本原理。然后我们描述了哺乳动物脑基因组中不同DNA修饰的概况。最后，我们讨论了DNA修饰在哺乳动物脑发育和功能中的作用。
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