表观遗传学、染色质与大脑发育及功能
Epigenetics, chromatin and brain development and function.
作者信息
Isles Anthony R
机构信息
MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.
出版信息
Brain Neurosci Adv. 2018 Nov 12;2:2398212818812011. doi: 10.1177/2398212818812011. eCollection 2018 Jan-Dec.
Research investigating epigenetics and chromatin function in brain and behaviour has mushroomed over the last two decades. And yet epigenetics as a biological concept predates the discovery in the 1950s of DNA as the principle mode of inheritance by over a decade. This review explores the past, present and future research into epigenetics as it relates to understanding brain development and function.
在过去二十年中，有关表观遗传学以及染色质在大脑和行为方面功能的研究迅速增长。然而，表观遗传学作为一个生物学概念，比20世纪50年代DNA作为主要遗传模式的发现还要早十多年。这篇综述探讨了与理解大脑发育和功能相关的表观遗传学的过去、现在和未来研究。
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