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肠易激综合征：当前及新出现的治疗选择

Irritable bowel syndrome: current and emerging treatment options.

作者信息

Peyton Lauren, Greene Joy

出版信息

P T. 2014 Aug;39(8):567-78.

PMID:25136255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4123807/
Abstract

Irritable bowel syndrome, a functional gastrointestinal disorder of uncertain pathophysiology, affects up to 55 million Americans. Medications available or in development include antispasmodics, antidepressants, and antidiarrheals.

摘要

肠易激综合征是一种病理生理学尚不明确的功能性胃肠疾病，影响着多达5500万美国人。现有的或正在研发的药物包括解痉药、抗抑郁药和止泻药。

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Am J Gastroenterol. 2014 Sep;109(9):1350-65; quiz 1366. doi: 10.1038/ajg.2014.148. Epub 2014 Jun 17.
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Probiotics, gut microbiota and health.益生菌、肠道微生物群与健康。
Med Mal Infect. 2014 Jan;44(1):1-8. doi: 10.1016/j.medmal.2013.10.002. Epub 2013 Nov 28.
3
Randomized clinical trial: macrogol/PEG 3350 plus electrolytes for treatment of patients with constipation associated with irritable bowel syndrome.随机临床试验：聚乙二醇/PEG 3350 联合电解质治疗与肠易激综合征相关的便秘患者。
Am J Gastroenterol. 2013 Sep;108(9):1508-15. doi: 10.1038/ajg.2013.197. Epub 2013 Jul 9.
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Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study.在一项 2 期研究中，Eluxadoline 使腹泻型肠易激综合征患者受益。
Gastroenterology. 2013 Aug;145(2):329-38.e1. doi: 10.1053/j.gastro.2013.04.006. Epub 2013 Apr 9.
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A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation.一项为期 12 周、随机、对照试验，伴有 4 周的随机撤药期，旨在评估利那洛肽治疗便秘型肠易激综合征的疗效和安全性。
Am J Gastroenterol. 2012 Nov;107(11):1714-24; quiz p.1725. doi: 10.1038/ajg.2012.255.
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