Tveit K M, Karlsen K O, Fosså S D, Flokkmann A, Guldvog I, Haffner J
Norwegian Radium Hospital, Montebello, Oslo, Norway.
Scand J Gastroenterol. 1989 Dec;24(10):1243-7. doi: 10.3109/00365528909090794.
Twenty-four patients with carcinoma of the anus were treated with a combined regimen of external irradiation (50 Gy) and mitomycin C and 5-fluorouracil. A relatively large number of patients with locally advanced disease were included. A local complete response rate of 87.5% was obtained. The major acute toxicity was dermatitis/mucositis, necessitating a split course in 14 cases. After treatment four patients had persistent anal incontinence. After an observation period of 40-70 months 14 of the patients were alive without disease. We conclude that the conservative combined radiotherapy/chemotherapy regimen is an effective treatment also of advanced anal carcinoma, with tolerable toxicity and with promising survival results.
24例肛管癌患者接受了外照射（50 Gy）联合丝裂霉素C和5-氟尿嘧啶的综合治疗方案。纳入了相对较多局部晚期疾病患者。局部完全缓解率为87.5%。主要的急性毒性反应是皮炎/粘膜炎，14例患者需要采用分割疗程。治疗后4例患者出现持续性肛门失禁。经过40 - 70个月的观察期，14例患者存活且无疾病。我们得出结论，保守的放化疗联合方案也是晚期肛管癌的有效治疗方法，毒性可耐受，生存结果有望。
