糖尿病作为开角型青光眼的一个危险因素：一项系统评价和荟萃分析。
Diabetes mellitus as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.
作者信息
Zhou Minwen, Wang Wei, Huang Wenbin, Zhang Xiulan
机构信息
Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China; Shanghai Key Laboratory of Fundus Disease, Shanghai, China.
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, People's Republic of China.
出版信息
PLoS One. 2014 Aug 19;9(8):e102972. doi: 10.1371/journal.pone.0102972. eCollection 2014.
OBJECTIVE
To determine the association between diabetes mellitus (DM) and primary open-angle glaucoma (POAG).
METHODS
This is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases (PubMed and Embase) and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively.
RESULTS
Thirteen studies--seven case-control studies and six population-based cohort studies--were included in this meta-analysis. The pooled RR of the association between DM and POAG based on the risk estimates of the six cohort studies was 1.40 (95% CI, 1.25-1.57). The pooled OR of the association between DM and POAG based on the risk estimates of the seven case-control studies was 1.49 (95% CI, 1.17-1.88). There was considerable heterogeneity among the case-control studies that reported an association between DM mellitus and POAG (P<0.001) and no significant heterogeneity among the cohort studies (P = 0.377). After omitting the case-control study that contributed significantly to the heterogeneity, the pooled OR for the association between DM and POAG was 1.35 (95% CI, 1.06-1.74).
CONCLUSIONS
Individuals with DM have an increased risk of developing POAG.
目的
确定糖尿病（DM）与原发性开角型青光眼（POAG）之间的关联。
方法
这是一项对病例对照研究和队列研究的系统评价与荟萃分析。文献检索包括两个数据库（PubMed和Embase）以及检索到的研究的参考文献列表。使用随机效应模型分别对病例对照研究和队列研究进行荟萃分析，结果分别报告为调整后的比值比（OR）和相对风险（RR）。
结果
本荟萃分析纳入了13项研究——7项病例对照研究和6项基于人群的队列研究。基于6项队列研究的风险估计，DM与POAG之间关联的合并RR为1.40（95%CI，1.25 - 1.57）。基于7项病例对照研究的风险估计，DM与POAG之间关联的合并OR为1.49（95%CI，1.17 - 1.88）。报告DM与POAG之间存在关联的病例对照研究存在相当大的异质性（P<0.001），而队列研究中无显著异质性（P = 0.377）。在剔除对异质性有显著贡献的病例对照研究后，DM与POAG之间关联的合并OR为1.35（95%CI，1.06 - 1.74）。
结论
糖尿病患者患POAG的风险增加。
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