Liu Y X
Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing, PRC.
Sci China B. 1989 Dec;32(12):1449-56.
Several studies indicate that substances synthesized by granulosa cells are capable of regulating oocyte activity. We have studied the effect of factors synthesized by granulosa cells on tPA activity of denuded oocytes using a co-culture system. The results show that an FSH-dependent factor(s) synthesized by granulosa cells (but not by theca-interstitial cells) is capable of stimulating tPA activity of denuded oocytes. This finding is important for understanding hormonal regulation of oocyte tPA activity by mediators synthesized in granulosa cells.
多项研究表明，颗粒细胞合成的物质能够调节卵母细胞的活性。我们利用共培养系统研究了颗粒细胞合成的因子对裸卵组织型纤溶酶原激活物（tPA）活性的影响。结果显示，颗粒细胞（而非卵泡膜间质细胞）合成的一种促卵泡激素（FSH）依赖性因子能够刺激裸卵的tPA活性。这一发现对于理解颗粒细胞合成的介质对卵母细胞tPA活性的激素调节具有重要意义。
