蛋白质缺乏大鼠脑线粒体生物能量学的变化
Changes in brain mitochondrial bioenergetics in protein-deficient rats.
作者信息
Olorunsogo O O
机构信息
Biochemistry Department, College of Medicine, University of Ibadan, Nigeria.
出版信息
Br J Exp Pathol. 1989 Dec;70(6):607-19.
An assessment of mitochondrial bioenergetics in protein-malnourished rats indicates that there is a reduction of brain mitochondrial metabolism in protein malnutrition. Specifically, mitochondria of protein-malnourished offspring of malnourished rats exhibit (i) an enhancement of state 4 respiration, (ii) a reduction of ADP-stimulated state 3 respiration, (iii) a decrease in ADP:O ratios, (iv) reductions of FCCP-induced ATPase action and in the rates of proton and calcium ion translocation, and (v) diminished activities of redox enzymes. In general, these changes are less pronounced in malnourished weanling rats born of healthy dams. Although the exact molecular mechanism of these defects is not yet known, the alterations are definitely caused by diet-induced changes in the structure and integrity of inner mitochondrial membrane components.
对蛋白质营养不良大鼠的线粒体生物能量学评估表明，蛋白质营养不良会导致脑线粒体代谢降低。具体而言，营养不良大鼠的蛋白质营养不良后代的线粒体表现出：（i）状态4呼吸增强；（ii）ADP刺激的状态3呼吸降低；（iii）ADP：O比率降低；（iv）FCCP诱导的ATP酶活性以及质子和钙离子转运速率降低；（v）氧化还原酶活性减弱。总体而言，这些变化在健康母鼠所生的营养不良断奶大鼠中不太明显。尽管这些缺陷的确切分子机制尚不清楚，但这些改变肯定是由饮食引起的线粒体内膜成分结构和完整性变化所导致的。
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