Bae Jong-Myon, Shin Sang Yop, Kim Eun Hee
Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.
Korea Medical Institute, Seoul, Korea.
J Prev Med Public Health. 2014 Jul;47(4):201-5. doi: 10.3961/jpmph.2014.47.4.201. Epub 2014 Jul 31.
This retrospective cohort study aimed to estimate the mean sojourn time (MST) of preclinical gastric cancer in Korean men.
The subjects consisted of voluntary male screenees aged 40 to 69 years who underwent subsequent screening gastroscopies after testing negative at a baseline screening performed between January 2007 and December 2011. A new case was defined if gastric cancer cells were present in the biopsy specimens obtained from gastroscopy. The follow-up period was calculated as the number of person-years between the date of baseline screening gastroscopy and positive findings at a subsequent screening. The MST was calculated using transition rates of gastric cancer to determine the best screening interval.
Of the 171 979 voluntary male screenees, 61 688 (36%) underwent subsequent screening gastroscopies between January 2007 and December 2011. A total of 91 incident cases were found during 19 598 598 person-years of follow-up. The MST of gastric cancer was 2.37 years (95% confidence intervals, 1.92 to 2.96), and those aged 40 to 49 years had a shorter MST than those 50 to 69 years did.
These findings support the 2-year interval of screening recommended by the nationwide gastric cancer screening program in Korea. Further studies for the age-specific MST among women are needed.
This retrospective cohort study aimed to estimate the mean sojourn time (MST) of preclinical gastric cancer in Korean men.
The subjects consisted of voluntary male screenees aged 40 to 69 years who underwent subsequent screening gastroscopies after testing negative at a baseline screening performed between January 2007 and December 2011. A new case was defined if gastric cancer cells were present in the biopsy specimens obtained from gastroscopy. The follow-up period was calculated as the number of person-years between the date of baseline screening gastroscopy and positive findings at a subsequent screening. The MST was calculated using transition rates of gastric cancer to determine the best screening interval.
Of the 171 979 voluntary male screenees, 61 688 (36%) underwent subsequent screening gastroscopies between January 2007 and December 2011. A total of 91 incident cases were found during 19 598 598 person-years of follow-up. The MST of gastric cancer was 2.37 years (95% confidence intervals, 1.92 to 2.96), and those aged 40 to 49 years had a shorter MST than those 50 to 69 years did.
These findings support the 2-year interval of screening recommended by the nationwide gastric cancer screening program in Korea. Further studies for the age-specific MST among women are needed.
这项回顾性队列研究旨在估算韩国男性临床前期胃癌的平均停留时间（MST）。
研究对象为年龄在40至69岁之间的男性自愿筛查者，他们在2007年1月至2011年12月期间进行的基线筛查呈阴性后，接受了后续的胃镜筛查。如果从胃镜活检标本中发现胃癌细胞，则定义为新病例。随访期计算为从基线筛查胃镜检查日期到后续筛查阳性结果之间的人年数。使用胃癌的转变率计算MST，以确定最佳筛查间隔。
在171979名男性自愿筛查者中，有61688人（36%）在2007年1月至2011年12月期间接受了后续胃镜筛查。在19598598人年的随访期间，共发现91例新发病例。胃癌的MST为2.37年（95%置信区间为1.92至2.96），40至49岁的男性MST比50至69岁的男性短。
这些发现支持了韩国全国性胃癌筛查计划推荐的2年筛查间隔。需要进一步研究女性中特定年龄的MST。
这项回顾性队列研究旨在估算韩国男性临床前期胃癌的平均停留时间（MST）。
研究对象为年龄在40至69岁之间的男性自愿筛查者，他们在2007年1月至2011年12月期间进行的基线筛查呈阴性后，接受了后续的胃镜筛查。如果从胃镜活检标本中发现胃癌细胞，则定义为新病例。随访期计算为从基线筛查胃镜检查日期到后续筛查阳性结果之间的人年数。使用胃癌的转变率计算MST，以确定最佳筛查间隔。
在171979名男性自愿筛查者中，有61688人（36%）在2007年1月至2011年12月期间接受了后续胃镜筛查。在19598598人年的随访期间，共发现91例新发病例。胃癌的MST为2.37年（95%置信区间为1.92至2.96），40至49岁的男性MST比50至69岁的男性短。
这些发现支持了韩国全国性胃癌筛查计划推荐的2年筛查间隔。需要进一步研究女性中特定年龄的MST。
