Gu Li-Ze, Jiang Teng, Cheng Zao-Huo, Zhang Yue-Chun, Ou Meng-Meng, Chen Min-Chi, Zhou Zhen-He, Ling Wei-Ming
Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China; The Office of President, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
Neurosci Lett. 2014 Oct 3;581:42-5. doi: 10.1016/j.neulet.2014.08.018. Epub 2014 Aug 17.
A recent genome-wide association study indicated that rs11098403, a single nucleotide polymorphism in the vicinity of NDST3, was strongly associated with the risk of schizophrenia in Caucasians. However, this relation has not been validated in other populations or ethnic groups. Herein, we conducted a case-control study to investigate the association of rs11098403 polymorphism with the schizophrenia risk in a Han Chinese population comprising 440 schizophrenia patients and 450 control subjects. For the first time, we showed that the minor allele (G) of rs11098403 is closely associated with a reduced risk of schizophrenia (OR=0.614; 95% CI: 0.453-0.833; P=0.002; Power=0.832). Meanwhile, the G allele of rs11098403 seemed to reduce the schizophrenia risk via a dominant manner (GG+AG vs. AA, OR=0.526; 95% CI: 0.374-0.74; P<0.001). Furthermore, this association was further confirmed using an independent replication sample containing 267 schizophrenia patients and 400 control subjects with a Han Chinese descent (OR=0.652; 95% CI: 0.469-0.907; P=0.011; Power=0.772). Taken together, these findings demonstrate a significant association between rs11098403 and schizophrenia risk in Han Chinese, confirming the data that previously obtained from Caucasians.
最近一项全基因组关联研究表明，NDST3附近的单核苷酸多态性rs11098403与高加索人中精神分裂症的风险密切相关。然而，这种关系尚未在其他人群或种族中得到验证。在此，我们进行了一项病例对照研究，以调查rs11098403多态性与汉族人群中精神分裂症风险的关联，该汉族人群包括440例精神分裂症患者和450例对照。首次发现，rs11098403的次要等位基因（G）与精神分裂症风险降低密切相关（OR=0.614；95%CI：0.453-0.833；P=0.002；检验效能=0.832）。同时，rs11098403的G等位基因似乎以显性方式降低精神分裂症风险（GG+AG与AA相比，OR=0.526；95%CI：0.374-0.74；P<0.001）。此外，使用一个独立的复制样本（包括267例精神分裂症患者和400例汉族对照）进一步证实了这种关联（OR=0.652；95%CI：0.469-0.907；P=0.011；检验效能=0.772）。综上所述，这些发现表明rs11098403与汉族人群中精神分裂症风险之间存在显著关联，证实了先前在高加索人中获得的数据。
