Wang Lin, Chen Jianhua, Li Zhiqiang, Sun Weiming, Chen Boyu, Li Sining, Li Weidong, Lu Dajiang, Wang Yonggang, Shi Yongyong
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), The Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, P. R. China.
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):3-9. doi: 10.1002/ajmg.b.32573. Epub 2017 Nov 15.
The NDST3 gene at 4q26 was a functional candidate gene for mental disorders. Recently, a novel genome-wide significant risk locus at chromosome 4q26 was identified and the top single nucleotide polymorphism rs11098403 in the vicinity of NDST3 gene was reported to confer risk of schizophrenia in Caucasian. Nevertheless, association between NDST3 gene polymorphisms and schizophrenia, bipolar disorder, or major depressive disorders has not been well studied in the Han Chinese population. To further investigate whether NDST3 is a risk gene for these mental disorders, we genotyped and analyzed eight tag SNPs (rs11098403, rs10857057, rs2389521, rs4833564, rs6837896, rs7689157, rs3817274, rs609512) covering NDST3 gene in 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls of Chinese origin. However, there was no significant difference in allelic or genotypic frequency observed between each case group and healthy controls. Accordingly, our study does not support that the NDST3 gene plays a major role in schizophrenia, bipolar disorder, and major depressive disorder in the Han Chinese population.
位于4q26的NDST3基因是精神障碍的一个功能性候选基因。最近，在4q26染色体上发现了一个新的全基因组显著风险位点，据报道，NDST3基因附近的顶级单核苷酸多态性rs11098403会增加高加索人患精神分裂症的风险。然而，在汉族人群中，NDST3基因多态性与精神分裂症、双相情感障碍或重度抑郁症之间的关联尚未得到充分研究。为了进一步研究NDST3是否是这些精神障碍的风险基因，我们对1248例精神分裂症患者、1056例重度抑郁症患者、1344例双相情感障碍患者以及1248例中国汉族对照人群进行了基因分型，并分析了覆盖NDST3基因的8个标签单核苷酸多态性（rs11098403、rs10857057、rs2389521、rs4833564、rs6837896、rs7689157、rs3817274、rs609512）。然而，在每个病例组和健康对照组之间，未观察到等位基因或基因型频率存在显著差异。因此，我们的研究不支持NDST3基因在汉族人群的精神分裂症、双相情感障碍和重度抑郁症中起主要作用。
