CT灌注成像在头颈部鳞状细胞癌治疗反应监测及预测中的作用
Role of CT perfusion in monitoring and prediction of response to therapy of head and neck squamous cell carcinoma.
作者信息
Preda Lorenzo, Calloni Sonia Francesca, Moscatelli Marco Elvio Manlio, Cossu Rocca Maria, Bellomi Massimo
机构信息
Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy.
Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy ; University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
出版信息
Biomed Res Int. 2014;2014:917150. doi: 10.1155/2014/917150. Epub 2014 Jul 21.
Abstract
This review aims to summarize the technique and clinical applications of CT perfusion (CTp) of head and neck cancer. The most common pathologic type (90%) of head and neck cancer is squamous cell carcinoma (HNSCC): its diagnostic workup relies on CT and MRI, as they provide an accurate staging for the disease by determining tumour volume, assessing its extension, and detecting of lymph node metastases. Compared with conventional CT and MRI, CTp allows for obtaining measures of tumour vascular physiology and functional behaviour, and it has been demonstrated to be a feasible and useful tool in predicting local outcomes in patients undergoing radiation therapy and chemotherapy and may help monitor both treatments.
摘要
本综述旨在总结头颈部癌CT灌注（CTp）技术及其临床应用。头颈部癌最常见的病理类型（90%）是鳞状细胞癌（HNSCC）：其诊断检查依赖于CT和MRI，因为它们通过确定肿瘤体积、评估其范围以及检测淋巴结转移为疾病提供准确分期。与传统CT和MRI相比，CTp能够获取肿瘤血管生理学和功能行为的相关测量值，并且已被证明是预测接受放疗和化疗患者局部预后的一种可行且有用的工具，还可能有助于监测这两种治疗。
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