Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom.
Diagnostic Imaging Section, Clinique Vétérinaire Universitaire, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
J Vet Intern Med. 2023 May-Jun;37(3):1146-1154. doi: 10.1111/jvim.16722. Epub 2023 Apr 24.
Treatment of nasal tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion.
To assess perfusion parameters of nasal tumors (correlating with tumor type) before and during radiotherapy (RT) and find potential correlation with survival.
Twenty-four client-owned dogs with nasal tumors, including 16 epithelial tumors and 8 sarcomas.
Prospective cross-sectional study. All dogs had baseline DCECT to assess fractional vascular volume (BV), blood flow (BF), and transit time (TT). Thirteen dogs had repeat DCECT after 12 Gy of megavoltage RT. Survival times were calculated.
Median BV was 17.83 mL/100 g (range, 3.63-66.02), median BF was 122.63 mL/100 g/minute (range, 23.65-279.99), and median TT was 8.91 seconds (range, 4.57-14.23). Sarcomas had a significantly lower BF than adenocarcinomas (P = .002), carcinomas (P = .01), and other carcinomas (P = .001), and significantly lower BV than adenocarcinomas (P = .03) and other carcinomas (P = .004). Significant associations were found between epithelial tumors and sarcoma for change in tumor volume (P = .01), width (P = .004), and length (P = .02) in that epithelial tumors decreased in volume whereas sarcomas increased in volume. Perfusion parameters were not correlated with survival.
Nasal sarcomas have lower BV and BF than nasal carcinomas, and sarcomas have a lower size reduction than carcinomas early on during RT. Baseline results and changes in perfusion parameters may not be correlated with survival.
治疗犬的鼻腔肿瘤会导致高发病率，目前缺乏可靠的预后因素。动态对比增强计算机断层扫描（DCECT）可用于评估肿瘤灌注。
评估接受放疗（RT）前和治疗期间鼻腔肿瘤的灌注参数（与肿瘤类型相关），并寻找与生存相关的潜在相关性。
24 只患有鼻腔肿瘤的患犬，包括 16 例上皮肿瘤和 8 例肉瘤。
前瞻性病例对照研究。所有犬均行基线 DCECT 检查，以评估分容积（BV）、血流（BF）和通过时间（TT）。13 只犬在接受 12Gy 兆伏级 RT 后重复行 DCECT。计算生存时间。
中位 BV 为 17.83mL/100g（范围 3.63-66.02），中位 BF 为 122.63mL/100g/min（范围 23.65-279.99），中位 TT 为 8.91 秒（范围 4.57-14.23）。肉瘤的 BF 明显低于腺癌（P=.002）、癌（P=.01）和其他癌（P=.001），BV 明显低于腺癌（P=.03）和其他癌（P=.004）。上皮肿瘤与肉瘤之间存在肿瘤体积（P=.01）、宽度（P=.004）和长度（P=.02）变化的显著相关性，上皮肿瘤体积缩小，而肉瘤体积增大。灌注参数与生存无相关性。
与鼻腔癌相比，鼻腔肉瘤的 BV 和 BF 较低，肉瘤在 RT 早期的体积减小程度低于癌。基线结果和灌注参数的变化可能与生存无关。
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