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来自毛瓣木果楝种子的弱抗炎柠檬苦素类化合物。

Weakly anti-inflammatory limonoids from the seeds of Xylocarpus rumphii.

作者信息

Sarigaputi Chanin, Sommit Damrong, Teerawatananond Thapong, Pudhom Khanitha

机构信息

Program in Biotechnology and §Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.

出版信息

J Nat Prod. 2014 Sep 26;77(9):2037-43. doi: 10.1021/np5003687. Epub 2014 Aug 20.

Abstract

Seven new limonoids, namely, xylorumphiins E-J (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (8-10), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 μM, respectively.

摘要

从毛瓣木果楝种子中分离得到7个新柠檬苦素,即木果楝素E-J(1-2和4-7)和2-羟基木果楝素F(3),以及3个已知衍生物(8-10)。2-羟基木果楝素F(3)和木果楝素I(6)对脂多糖激活的巨噬细胞产生一氧化氮具有中等抑制活性,IC50值分别为24.5和31.3 μM。

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