大叶桃花心木种子中的柠檬苦素及其抗炎活性
Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities.
作者信息
Chen Li-Chai, Liao Hsiang-Ruei, Chen Pei-Yu, Kuo Wen-Lung, Chang Tsung-Hsien, Sung Ping-Jyun, Wen Zhi-Hong, Chen Jih-Jung
机构信息
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan.
出版信息
Molecules. 2015 Oct 12;20(10):18551-64. doi: 10.3390/molecules201018551.
A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values≤45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values≤36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.
从大叶桃花心木种子中分离出一种新的柠檬苦素——大叶桃花心木苦素（1），以及5种已知化合物（2 - 6）。通过广泛的一维/二维核磁共振和质谱分析确定了1的结构。大叶桃花心木苦素（1）、胡米内酯F（2）、3,6 - O,O - 二乙酰基苦内酯（3）、3 - O - 惕各酰基苦内酯（4）和大叶桃花心木宁E（5）对人中性粒细胞因甲酰 - L - 蛋氨酰 - L - 亮氨酰 - L - 苯丙氨酸（fMLP）刺激产生超氧阴离子具有抑制作用（IC50值≤45.44 μM）。化合物1、4、5和苦木素（6）对脂多糖（LPS）诱导的一氧化氮（NO）生成表现出强效抑制作用，IC50值≤36.32 μM。
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