Department of Chemistry, Kangwon National University , Chuncheon 200-701, Republic of Korea.
Org Lett. 2014 Sep 5;16(17):4602-5. doi: 10.1021/ol502174n. Epub 2014 Aug 21.
An efficient copper-TBAF-catalyzed C-N bond formation of sulfoximines with arylsiloxanes in dichloromethane at room temperature, affording the desired N-aryl sulfoximines in good to excellent yields under an oxygen atmosphere, is reported. This method complements the existing synthetic approaches due to some advantageous properties of arylsiloxanes such as availability, low toxicity, ease of handling, high stability, and environmental benignity under mild reaction conditions, thus opening a new approach to practical C-N bond formation.
本文报道了一种在室温下，以二氯甲烷为溶剂，以铜-TBAF 为催化剂，通过亚砜亚胺与芳基硅烷的 C-N 键形成反应，在氧气氛围中得到了所需的 N-芳基亚砜亚胺，产率良好至优秀。由于芳基硅烷具有易得、低毒、易于操作、高稳定性以及在温和的反应条件下环境友好等优点，该方法补充了现有的合成方法，为实用的 C-N 键形成开辟了新途径。
