Lightman J M, Townsend J C, Selvin G J
Department of Ophthalmology, University of California-Davis, Sacramento 95816.
J Am Optom Assoc. 1989 Nov;60(11):849-53.
Second generation oral hypoglycemic agents, such as glyburide and glipizide, are often the treatment of choice in non-insulin dependent diabetes mellitus. These sulfonylureas are more potent osmotic agents than their predecessors and may give rise to crystalline lens changes and refractive error shifts in the absence of blood glucose variation. Such a case is presented, as is a detailed description of the mechanism of action of commonly prescribed oral hypoglycemic agents.
第二代口服降糖药，如格列本脲和格列吡嗪，通常是非胰岛素依赖型糖尿病的首选治疗药物。这些磺酰脲类药物作为渗透剂比其前代产品更有效，并且在血糖无变化的情况下可能会引起晶状体改变和屈光不正偏移。本文报告了这样一个病例，并详细描述了常用口服降糖药的作用机制。
