Blackman R, Gross M, Seltzer S
J Endod. 1989 Feb;15(2):76-9. doi: 10.1016/s0099-2399(89)80112-8.
Pellets of a glass ionomer-silver cement and a zinc oxide-eugenol cement were implanted into the soft tissues and bones of 30 rats. Following experimental periods of 14, 30, and 80 days, the animals were killed and tissue sections were prepared. The responses to each of the materials initially and at 30 days consisted of mild inflammation. No severe inflammatory responses were noted in any of the groups. By 80 days, although mild inflammation persisted, the materials appeared to be well tolerated. Bone apposition occurred in the glass ionomer-silver cement group; the zinc oxide-eugenol group produced fibrosis.
将玻璃离子体银粘固粉和氧化锌丁香酚粘固粉制成的小球植入30只大鼠的软组织和骨骼中。在14天、30天和80天的实验期后，处死动物并制备组织切片。最初以及在30天时，对每种材料的反应均为轻度炎症。任何一组均未观察到严重的炎症反应。到80天时，尽管仍存在轻度炎症，但这些材料似乎耐受性良好。玻璃离子体银粘固粉组出现骨附着；氧化锌丁香酚组产生纤维化。
