From the Neurogenetics Unit (D.A., E.A.), Epilepsy Clinic (F.A.), and Neuroimmunology Unit (A.B.-O.), Montreal Neurological Hospital and Institute, Quebec, Canada; Departments of Neurology & Neurosurgery (D.A., F.A., E.A., A.B.-O.), Pediatrics (F.A.), and Human Genetics (E.A.), McGill University, Montreal, Quebec, Canada; Okmeydani Education and Research Hospital (D.K.), Istanbul, Turkey; Royal Victoria Infirmary (Y.H.), Newcastle-upon-Tyne, UK; Epilepsy Research Center (S.F.B.), Department of Medicine (Neurology), University of Melbourne, Australia; and Department of Neurology (K.L.), University of California at San Francisco.
Neurology. 2014 Sep 16;83(12):1049-55. doi: 10.1212/WNL.0000000000000791. Epub 2014 Aug 20.
To describe a potential association between comorbid autoimmune disease and Rasmussen encephalitis (RE) and discuss potential insights into underlying RE pathogenesis.
We report a case series of 4 patients with RE in whom a comorbid autoimmune disease was subsequently diagnosed and review the literature on possible common susceptibility factors.
In 4 patients who presented with typical clinical features of RE, a comorbid autoimmune disease was subsequently diagnosed: Hashimoto thyroiditis, ulcerative colitis, Crohn disease, and systemic lupus erythematosus. We discuss the possible common predisposing factors.
The association of RE, a rare entity, with a comorbid autoimmune disease raises the possibility of shared mechanisms of susceptibility, including common immunogenetic and/or environmental risk factors.
描述自身免疫性疾病共病与 Rasmussen 脑炎(RE)之间的潜在关联,并探讨潜在的 RE 发病机制的见解。
我们报告了 4 例 RE 患者的病例系列,这些患者随后被诊断出患有共病自身免疫性疾病,并回顾了可能存在的共同易感因素的文献。
在 4 例具有典型 RE 临床特征的患者中,随后诊断出共病自身免疫性疾病:桥本甲状腺炎、溃疡性结肠炎、克罗恩病和系统性红斑狼疮。我们讨论了可能存在的共同易患因素。
罕见实体 RE 与共病自身免疫性疾病的关联提出了易感性的共同机制的可能性,包括共同的免疫遗传和/或环境危险因素。