Iwamoto A, Sakita M, Hata K, Hagiwara A, Takahashi T
1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1989 Nov;90(11):1829-33.
Mitomycin C adsorbed onto activated carbon particles (MMC-CH) has been administered intraperitoneally for C57BL/6 mice. The weight of the spleen and thymus of the mice given MMC-CH was decreased lesser than those of the mice given mitomycin C aqueous solution (MMC-AQ). The number of peritoneal exudate cells (PEC) in the mice given MMC-AQ was decreased remarkably on 1st day after MMC-AQ administration and recovered within normal range on the 7th day. On the other hand, the number of PEC in the mice given MMC-CH was increased remarkably on the 1st day and then gradually decreased to normal range on the 7th day. Reactivity of spleen cells by Con A was inhibited in the spleen cells from the mice given MMC-AQ more than those from the mice given MMC-CH. Fifth percent lethal dose was 8.0mg/kg in the mice given MMC-AQ, and 18.2mg/kg in the mice given MMC-CH.
已将吸附在活性炭颗粒上的丝裂霉素C（MMC-CH）腹腔注射给C57BL/6小鼠。给予MMC-CH的小鼠脾脏和胸腺重量的减轻程度小于给予丝裂霉素C水溶液（MMC-AQ）的小鼠。给予MMC-AQ的小鼠腹腔渗出细胞（PEC）数量在给予MMC-AQ后第1天显著减少，并在第7天恢复到正常范围。另一方面，给予MMC-CH的小鼠PEC数量在第1天显著增加，然后在第7天逐渐降至正常范围。与给予MMC-CH的小鼠相比，给予MMC-AQ的小鼠脾脏细胞中，Con A对脾细胞反应性的抑制作用更强。给予MMC-AQ的小鼠的半数致死剂量为8.0mg/kg，给予MMC-CH的小鼠为18.2mg/kg。
