Takahashi T, Hagiwara A, Ito T
Gan To Kagaku Ryoho. 1984 Aug;11(8):1550-6.
When Mitomycin C, adsorbed on to activated carbon particles (MMC-CH) was administered intraperitoneally, it was absorbed well by the omentum and peritoneum, and eventually by the lymphatic system. MMC-CH yielded high drug concentrations in intraabdominal tissues and exhibited remarkably low levels in extra-abdominal tissues and peripheral blood. We conducted clinical trials with MMC-CH in 26 patients with carcinomatous peritonitis. High MMC concentrations persisted in ascites, while drug concentrations were extremely low in peripheral blood. Eighteen of the 26 patients studied responded well to MMC-CH and were able to tolerate about 5 times the conventional dose of MMC. Serious adverse effects were not observed, despite the administration of such a large dose.
当吸附在活性炭颗粒上的丝裂霉素C（MMC-CH）经腹腔给药时，它被大网膜和腹膜很好地吸收，最终被淋巴系统吸收。MMC-CH在腹腔内组织中产生高药物浓度，而在腹腔外组织和外周血中呈现极低水平。我们对26例癌性腹膜炎患者进行了MMC-CH的临床试验。腹水中丝裂霉素浓度持续较高，而外周血中的药物浓度极低。研究的26例患者中有18例对MMC-CH反应良好，能够耐受约5倍常规剂量的MMC。尽管给予了如此大的剂量，但未观察到严重不良反应。
