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长脉冲掺钕钇铝石榴石用于治疗小儿静脉畸形

The use of long pulsed neodymium-doped yttrium aluminum garnet for the treatment of paediatric venous malformations.

作者信息

Sofos Stratos, Liew Se Hwang

机构信息

Department of Plastic Surgery, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.

出版信息

Ann Dermatol. 2014 Aug;26(4):474-7. doi: 10.5021/ad.2014.26.4.474. Epub 2014 Jul 31.

Abstract

BACKGROUND

Venous malformation in the pediatric population can present with pain, bleeding, or a debilitating deformity that can be difficult to manage. Sclerotherapy, surgery, and more recently, long pulsed neodymium-doped yttrium aluminum garnet (Nd : YAG) laser have been used with variable success rates.

OBJECTIVE

Our aims and objectives, were to identify the specific group of patients that would benefit from this treatment.

METHODS

A prospective clinical trial was carried out with 59 consecutive patients. The treatment criteria included a large facial deformity and painful or bleeding lesions. One to three treatments were administered at 6~8-week intervals.

RESULTS

A total of 59 patients were treated. The average follow-up was 24 months. All patients achieved good to excellent results in pain and bleeding control as well as in the reduction of the size of lesions in the lip and oral mucosa. The treatment however, is not effective in reducing the size of large, relatively high-flow lesions in the limbs. Complications from treatment include skin blistering (n=4), ulceration (n=4), and subsequent hypertrophic scarring (n=3). Three patients had partial recurrence after a 3-year follow-up.

CONCLUSION

Complex venous malformations cannot be cured but can be symptomatically controlled with the long-pulsed Nd : YAG laser treatment. The treatment satisfaction is high, and there is a small but definite risk of scarring from treatment.

摘要

背景

儿科人群中的静脉畸形可表现为疼痛、出血或导致难以处理的致残性畸形。硬化疗法、手术以及最近的长脉冲掺钕钇铝石榴石(Nd:YAG)激光治疗的成功率各不相同。

目的

我们的目的是确定能从该治疗中获益的特定患者群体。

方法

对59例连续患者进行了一项前瞻性临床试验。治疗标准包括严重面部畸形以及疼痛或出血性病变。每隔6至8周进行1至3次治疗。

结果

共治疗了59例患者。平均随访24个月。所有患者在疼痛和出血控制以及唇部和口腔黏膜病变大小缩小方面均取得了良好至优异的效果。然而,该治疗对缩小四肢较大、相对高流量病变的大小无效。治疗并发症包括皮肤水疱(n = 4)、溃疡(n = 4)以及随后的肥厚性瘢痕形成(n = 3)。3例患者在3年随访后出现部分复发。

结论

复杂静脉畸形无法治愈,但长脉冲Nd:YAG激光治疗可对其症状进行控制。治疗满意度较高,且治疗存在一定但明确的瘢痕形成风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28d1/4135102/97ececdb26f3/ad-26-474-g001.jpg

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