Waldmann K H, Kikovic D, Stockhofe N
Zentralbl Veterinarmed A. 1989 Nov;36(9):676-86.
A pig grower ration containing olaquindox at a concentration of 778 mg/kg was accidentally fed to 10 respectively 16 weeks old weaner pigs. The subsequent intoxication was characterized by poor growth and long-term disturbances of renal function and electrolyte metabolism. A deficiency of aldosterone, produced by a selective degeneration of the arcuate zone of the adrenal cortex, is probably the cause of the hyponatremia, hyperkalemia and hemoconcentration observed. Simultaneously plasma levels of urea and creatinine were elevated five- to eightfold. Due to hyperkalemia episodes with collapse, paralysis and severe electrocardiographic changes occurred several times. Two pigs died in the course of such attacks. Individuals, which transiently showed distinct clinical symptoms of intoxication, did not show any signs of disease 15 or 18 weeks later. Therefore it may be assumed, that the lesions of the adrenals, heart and skeletal muscle caused by olaquindox intoxication are reversible in some cases.
一种含喹乙醇浓度为778毫克/千克的生猪育肥料被意外喂给了10头分别为16周龄的断奶仔猪。随后的中毒表现为生长不良以及肾功能和电解质代谢的长期紊乱。肾上腺皮质弓状带的选择性退化导致醛固酮缺乏，这可能是所观察到的低钠血症、高钾血症和血液浓缩的原因。同时，血浆尿素和肌酐水平升高了五到八倍。由于高钾血症发作，出现了几次虚脱、瘫痪和严重的心电图变化。在此类发作过程中有两头猪死亡。那些曾短暂出现明显中毒临床症状的个体，在15或18周后未显示出任何疾病迹象。因此可以假定，喹乙醇中毒引起的肾上腺、心脏和骨骼肌损伤在某些情况下是可逆的。
