Power S B, Donnelly W J, McLaughlin J G, Walsh M C, Dromey M F
Department of Agriculture and Food, Regional Veterinary Laboratory, Cork, Ireland.
Vet Rec. 1989 Apr 8;124(14):367-70. doi: 10.1136/vr.124.14.367.
A weaner ration containing carbadox at concentrations of 331 to 363 mg/kg was accidentally fed to suckling and weaned pigs in an 84 sow herd. Discarded ration was fed to 36 sows. One hundred and sixty five weaner pigs died in a 10 week period with clinical signs including refusal to eat, ill thrift, the passing of hard pelleted faeces, posterior paresis and death in seven to nine days. The surviving weaners did not thrive and some males showed poor testicular development. Sows and suckling pigs that consumed the ration also failed to thrive as did the progeny of affected sows. The main pathological finding was obliteration of the zona glomerulosa of the adrenal cortex. Increased potassium and decreased sodium concentrations in serum were the most notable and consistent biochemical findings.
一个含有浓度为331至363毫克/千克卡巴多司的断奶仔猪日粮，意外地喂给了一个拥有84头母猪的猪群中的哺乳仔猪和断奶仔猪。废弃的日粮喂给了36头母猪。在10周内，165头断奶仔猪死亡，临床症状包括拒食、生长不良、排出硬颗粒粪便、后肢麻痹以及在7至9天内死亡。存活的断奶仔猪生长不佳，一些公猪睾丸发育不良。食用该日粮的母猪和哺乳仔猪以及受影响母猪的后代也生长不良。主要病理发现是肾上腺皮质球状带消失。血清中钾浓度升高和钠浓度降低是最显著且一致的生化发现。
