Meng Xianyu, Liao Peiqiu, Liu Jianquan, Bi Xihe
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Chem Commun (Camb). 2014 Oct 14;50(80):11837-9. doi: 10.1039/c4cc04905e.
Divergent syntheses of indolizines and 2,4-disubstituted pyrroles by the silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides are reported. These methods provide an effective route to highly functionalized indolizines and 2,4-disubstituted pyrroles in good to excellent yields. The 2,4-disubstituted pyrroles are synthesized by an unprecedented regioselective [3+2] cycloaddition of terminal alkynes with isocyanides.
报道了通过银催化2-吡啶基炔基甲醇与异腈的环化反应，实现中氮茚和2,4-二取代吡咯的发散性合成。这些方法为高产率地合成高度官能化的中氮茚和2,4-二取代吡咯提供了一条有效途径。2,4-二取代吡咯是通过末端炔烃与异腈前所未有的区域选择性[3+2]环加成反应合成的。
