Perryman Lara, Erler Janine T
Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, Copenhagen 2200, Denmark.
Future Oncol. 2014;10(9):1709-17. doi: 10.2217/fon.14.39.
Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will breakdown the process of cancer progression and the various roles that LOX plays has in the advancement of cancer. We will highlight why LOX is an exciting therapeutic target for the future.
转移是癌症相关死亡的主要原因，迫切需要针对癌症进展的治疗方法。赖氨酰氧化酶（LOX）在癌症进展（包括转移）中起关键作用，因此是一个有吸引力的治疗靶点。在这篇综述中，我们将剖析癌症进展的过程以及LOX在癌症发展中所起的各种作用。我们将强调为什么LOX是未来一个令人兴奋的治疗靶点。
