染色体结构的维持：SMC 复合物的定位和功能。
The maintenance of chromosome structure: positioning and functioning of SMC complexes.
机构信息
Karolinska Institutet, Department of Cell and Molecular Biology, von Eulers väg 3, 171 77 Stockholm, Sweden.
University of Tokyo, Institute of Molecular and Cellular Biosciences, Laboratory of Genome Structure and Function Research Center for Epigenetic Disease, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
出版信息
Nat Rev Mol Cell Biol. 2014 Sep;15(9):601-14. doi: 10.1038/nrm3857.
Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics and control sister chromatid cohesion, chromosome condensation, DNA replication, DNA repair and transcription. Even though the molecular mechanisms that lead to this large range of functions are still unclear, it has been established that the complexes execute their functions through their association with chromosomal DNA. A large set of data also indicates that SMC complexes work as intermolecular and intramolecular linkers of DNA. When combining these insights with results from ongoing analyses of their chromosomal binding, and how this interaction influences the structure and dynamics of chromosomes, a picture of how SMC complexes carry out their many functions starts to emerge.
染色体结构维持（SMC）复合物，包括真核细胞中的黏合蛋白、凝聚素和 Smc5/6 复合物，是染色体动力学的核心调节剂，控制着姐妹染色单体的黏合、染色体的凝聚、DNA 的复制、DNA 的修复和转录。尽管导致这些广泛功能的分子机制尚不清楚，但已经确定复合物通过与染色体 DNA 的结合来执行其功能。大量数据还表明，SMC 复合物作为 DNA 的分子间和分子内连接物。当将这些见解与正在进行的对其染色体结合的分析结果以及这种相互作用如何影响染色体的结构和动力学相结合时，就可以了解 SMC 复合物如何执行其众多功能。
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