SMC 复合物对染色体 DNA 的组织作用。

Organization of Chromosomal DNA by SMC Complexes.

机构信息

Laboratory of Molecular Biology, Medical Research Council, Cambridge University, Cambridge CB2 0QH, United Kingdom.

Department of Biochemistry, Oxford University, Oxford OX1 3QU, United Kingdom; email:

出版信息

Annu Rev Genet. 2019 Dec 3;53:445-482. doi: 10.1146/annurev-genet-112618-043633. Epub 2019 Oct 2.

DOI:10.1146/annurev-genet-112618-043633

PMID:31577909

Abstract

Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases.

摘要

结构维持染色体（SMC）复合物是所有生命领域染色体结构的关键组织者。尽管它们的功能看似不同，如染色体分离、染色体维持、姐妹染色单体黏合和有丝分裂染色体浓缩，但这些复合物似乎通过高度保守的机制发挥作用，并且它们代表了一类新型的 DNA 转位酶。