Mantovani A, Dejana E
Immunol Today. 1989 Nov;10(11):370-5. doi: 10.1016/0167-5699(89)90270-3.
Hemostasis, inflammatory reactions and immunity involve close interactions between immunocompetent cells and the vascular endothelium. Cytokines, produced by and acting on endothelial cells, are mediators of the complex bidirectional interactions between leukocytes and vascular cells. Cytokines affect endothelial cell function in inflammation, thrombosis and angiogenesis, in addition to their role as accessory cells. As well as acting as targets for the action of cytokines, endothelial cells are important producers of polypeptide mediators that regulate hematopoiesis, the differentiation and proliferation of T and B cells and the extravasation of leukocytes. In this review, Alberto Mantovani and Elisabetta Dejana discuss endothelial cells as important participants in the induction and regulation of coagulation, inflammation and immunity and cytokines as crucial mediators of the symbiotic interactions between vascular cells and leukocytes.
止血、炎症反应和免疫涉及免疫活性细胞与血管内皮之间的密切相互作用。由内皮细胞产生并作用于内皮细胞的细胞因子，是白细胞与血管细胞之间复杂双向相互作用的介质。细胞因子除了作为辅助细胞发挥作用外，还在炎症、血栓形成和血管生成中影响内皮细胞功能。内皮细胞不仅是细胞因子作用的靶点，还是调节造血、T细胞和B细胞的分化与增殖以及白细胞外渗的多肽介质的重要产生者。在这篇综述中，阿尔贝托·曼托瓦尼和伊丽莎白·德亚纳讨论了内皮细胞作为凝血、炎症和免疫诱导与调节的重要参与者，以及细胞因子作为血管细胞与白细胞之间共生相互作用的关键介质。
