Chakrabarti M K, Holdcroft A, Sapsed-Byrne S, Whitwam J G
Royal Postgraduate Medical School, Hammersmith Hospital, London.
Br J Anaesth. 1989 Dec;63(6):732-5. doi: 10.1093/bja/63.6.732.
Surfactant depletion was induced by lung lavage in 10 rabbits. Ascending aortic blood flow was measured at normocapnia at 0, 5 and 10 cm H2O PEEP before and after lavage. Aortic blood flow was reduced by PEEP, by a maximum of 24% before lavage and 60% after lavage. It was concluded that, although adequate arterial oxygenation can be maintained with 10 cm H2O PEEP in surfactant-depleted rabbit's lungs, the circulatory impairment may result in inadequate oxygen delivery.
通过对10只兔子进行肺灌洗来诱导表面活性剂耗竭。在灌洗前后，分别在0、5和10 cm H₂O呼气末正压（PEEP）下的正常碳酸血症状态下测量升主动脉血流量。呼气末正压会降低主动脉血流量，灌洗前最大降低24%，灌洗后降低60%。得出的结论是，虽然在表面活性剂耗竭的兔肺中使用10 cm H₂O呼气末正压可以维持足够的动脉氧合，但循环障碍可能导致氧输送不足。
