Argiras E P, Blakeley C R, Dunnill M S, Otremski S, Sykes M K
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford.
Br J Anaesth. 1987 Oct;59(10):1278-85. doi: 10.1093/bja/59.10.1278.
Lung lavage was performed in 16 anaesthetized rabbits to produce surfactant-deficient lungs. This resulted in alveolar collapse, an arterial PO2 of less than 15 kPa on 100% oxygen and an inflection point on the inspiratory limb of the pressure-volume curve at an airway pressure of 8-10 mm Hg. One group of eight animals was then ventilated with a positive end-expiratory pressure (PEEP) equal to the pressure at the inflection point, whilst the second group of eight was ventilated with a PEEP 5 mm Hg less than the inflection point. Animals in the high PEEP group had a significantly greater arterial PO2 than those in the low PEEP group, but the mean survival time for each group was similar. However, there was a significantly greater incidence of hyaline membranes in the low PEEP group. Various mechanisms to explain these findings are discussed.
对16只麻醉的兔子进行肺灌洗，以制造表面活性剂缺乏的肺。这导致肺泡萎陷、在吸入100%氧气时动脉血氧分压低于15kPa，以及压力-容积曲线吸气支在气道压力8-10mmHg处出现一个拐点。然后，一组8只动物以等于拐点处压力的呼气末正压（PEEP）进行通气，而另一组8只动物以比拐点处压力低5mmHg的PEEP进行通气。高PEEP组动物的动脉血氧分压显著高于低PEEP组，但每组的平均存活时间相似。然而，低PEEP组透明膜的发生率显著更高。文中讨论了解释这些发现的各种机制。
